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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MC4R
All Species:
20.91
Human Site:
S116
Identified Species:
51.11
UniProt:
P32245
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P32245
NP_005903.2
332
36943
S116
S
T
D
T
D
A
Q
S
F
T
V
N
I
D
N
Chimpanzee
Pan troglodytes
Q9TT23
325
36628
H113
I
A
D
A
F
V
R
H
I
D
N
V
F
D
S
Rhesus Macaque
Macaca mulatta
Q864J4
317
34745
V112
A
L
V
A
R
A
A
V
V
Q
Q
L
D
N
V
Dog
Lupus familis
XP_541099
632
70219
A416
K
H
V
V
I
A
D
A
F
V
R
H
I
D
N
Cat
Felis silvestris
Mouse
Mus musculus
P56450
332
36970
S116
S
T
D
T
D
A
Q
S
F
T
V
N
I
D
N
Rat
Rattus norvegicus
P70596
332
36868
S116
S
T
D
T
D
A
Q
S
F
T
V
N
I
D
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505445
334
36107
S118
T
D
G
G
A
A
Q
S
F
A
V
N
I
D
N
Chicken
Gallus gallus
NP_001026685
331
36978
S115
N
I
D
T
D
A
Q
S
F
T
I
N
I
D
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_775385
326
36403
S114
G
N
L
T
N
R
E
S
I
I
K
N
M
D
N
Tiger Blowfish
Takifugu rubipres
NP_001027732
322
35956
T112
G
T
L
T
I
P
A
T
L
I
K
S
M
D
N
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.7
47.8
35.9
N.A.
93.6
93.3
N.A.
82.3
87
N.A.
69.8
66.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
75.3
64.4
44.1
N.A.
97.2
96.9
N.A.
87.7
91.5
N.A.
81.3
79.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
6.6
33.3
N.A.
100
100
N.A.
60
80
N.A.
33.3
26.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
20
46.6
N.A.
100
100
N.A.
66.6
93.3
N.A.
53.3
46.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
20
10
70
20
10
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
50
0
40
0
10
0
0
10
0
0
10
90
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
10
0
0
0
60
0
0
0
10
0
0
% F
% Gly:
20
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
10
0
0
0
0
0
10
0
0
0
10
0
0
0
% H
% Ile:
10
10
0
0
20
0
0
0
20
20
10
0
60
0
0
% I
% Lys:
10
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% K
% Leu:
0
10
20
0
0
0
0
0
10
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% M
% Asn:
10
10
0
0
10
0
0
0
0
0
10
60
0
10
80
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
50
0
0
10
10
0
0
0
0
% Q
% Arg:
0
0
0
0
10
10
10
0
0
0
10
0
0
0
0
% R
% Ser:
30
0
0
0
0
0
0
60
0
0
0
10
0
0
10
% S
% Thr:
10
40
0
60
0
0
0
10
0
40
0
0
0
0
0
% T
% Val:
0
0
20
10
0
10
0
10
10
10
40
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _